xxxHOLIC is the story of Watanuki Kimihiro (family - given), a bewildered boy with the "power" to see spirits and ghosts. One day, as Watanuki is chased by ghosts, his visions are dispelled as he touches the fence of a strange house. As he gets up, he is dragged into the house, and meets a "shop owner" named Ichihara Yuko. Yuko is actually a powerful witch who runs a shop that grants all kinds of wishes, but asks for a price of an equal value.

Yuko almost automatically senses that Watanuki has the power of spiritual sight, and makes a deal with him so that he can be rid of his "curse." Instead of paying a price upfront, he can work at her shop until he earns enough credit to get his wish granted. Although Watanuki does menial tasks, this experience at Yuko's shop is one not to be forgotten.